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Cialis is an erectile dysfunction treatment that lasts for upto 36 hours, over 6 times longer than its nearest rivals. Its long lasting properties mean that men no longer have to worry if they'll be ready to have sex. Cialis works for 88% of men to achieve a strong erection, at any time they want, upto 36 hours after first taking a single Cialis tablet.

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(1). Treating erectile dysfunction(impotence), A man is impotent if he cannot achieve or sustain an erect penis for sexual activity; (2). Cialis stays in your body for 36hrs, it allows you to choose the right moment; (3). Cialis has been shown to work safely and effectively in adult men with erectile dysfunction(ED).Cialis remain active in the body in the following 24-36 hours. This means that Cialis allows you to achieve and maintain an erection easier than normal within this period.
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When an erection goes limp, you have PDE5 to thank.
Specialized penis tissue produces a substance called cyclic guanosine monophosphate (cGMP) in response to sexual stimulation. The more cGMP available, the more Durable the erection. Cialis inhibits the PDE5 enzyme, preserving cGMP levels, therefore aiding erection viability and durability.

Cialis is a member of a family of drugs known as PDE5 enzyme inhibitors.
Cialis is known as the "36 hour pill" or the "weekend pill" because unlike other similar drugs, Cialis has a long duration of action.
Cialis blocks an enzyme that causes an erection to go flaccid. Although Cialis is similar to Levitra and Viagra, its dose, onset of action, and duration of action is unique.
Cialis is a member of a family of drugs called PDE5 Inhibitors. Cialis is now marketed in approximately 40 countries and is available by prescription in pharmacies on five continents.
Cialis was developed by Icos, a small biotech company located in Washington State. Icos formed a 50/50 joint venture with Eli Lilly & company. Eventually, Lilly bought out Icos.

The BIG Discovery: cyclic guanosine monophosphate (cGMP)
When a man gets sexually stimulated, a chain reaction occurs in the tissue of the penis that results in elevated levels of a substance called cyclic guanosine monophosphate (cGMP).
As long as there are sufficient levels of cGMP, the penis can remain erect. The more cGMP, the more robust and durable the erection.
If you inhibit the degradation of cGMP it stays around in the penis longer, producing a more durable erection.

Cialis is that it preserves the elevated levels of cGMP that are created when a man is sexually stimulated for a stronger, more durable erection.
Cialis blocks the enzyme phosphodiesterase-5 (PDE5) which is responsible for the neutralization of cGMP. Cialis (tadalafil) is a highly selective inhibitor of PDE5. (PDE5 is not the only phosphodiesterase involved in the erectile physiology but it appears to be the most important one).

The nice thing about Cialis is that it won't cause erections at inappropriate times because it only blocks degradation of cGMP produced in reaction to sexual stimulation, such as thinking about something sexy. If you are not being sexually stimulated, there is no cGMP to protect, so the drug remains in the background.

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